Functional Characterization and Structural Analysis of NADH Oxidase Mutants from <em>Thermus thermophilus</em> HB27: Role of Residues 166, 174, and 194 in the Catalytic Properties and Thermostability

The <i>Thermus thermophilus</i> strain HB27 NADH-oxidase (Tt27-NOX) catalyzes the oxidation of nicotinamide adenine dinucleotide (NAD(P)H) by reducing molecular oxygen to hydrogen peroxide in a two-electron transfer mechanism. Surprisingly, Tt27-NOX showed significant differences in catalytic proper...

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Bibliografski detalji

Glavni autori:	Javier Rocha-Martin, Pedro A. Sánchez-Murcia, Fernando López-Gallego, Aurelio Hidalgo, José Berenguer, José M. Guisan
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2019-10-01
Serija:	Microorganisms
Teme:	nadh oxidase cofactor regeneration hydrogen peroxide dehydrogenase nad<sup>+</sup> extremophiles
Online pristup:	https://www.mdpi.com/2076-2607/7/11/515
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