The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions

ABSTRACT Trypanosoma cruzi, the agent of Chagas disease, accumulates polyphosphate (polyP) and Ca2+ inside acidocalcisomes. The alkalinization of this organelle stimulates polyP hydrolysis and Ca2+ release. Here, we report that histidine ammonia lyase (HAL), an enzyme that catalyzes histidine deamin...

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Detalhes bibliográficos

Principais autores:	Brian S. Mantilla, Cristina Azevedo, Paul W. Denny, Adolfo Saiardi, Roberto Docampo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2021-12-01
coleção:	mBio
Assuntos:	acidocalcisome alkalinization histidine ammonia lyase polyphosphate Trypanosoma cruzi
Acesso em linha:	https://journals.asm.org/doi/10.1128/mBio.01981-21
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