Independent validation and outlier analysis of EuroPOND Alzheimer’s disease staging model using ADNI and real-world clinical data

Abstract Background Event-based modeling (EBM) traces sequential progression of events in complex processes like neurodegenerative diseases, adept at handling uncertainties. This study validated an EBM for Alzheimer’s disease (AD) staging designed by EuroPOND, an EU-funded Horizon 2020 project, usin...

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Principais autores:	Mandy M. J. Wittens, Diana M. Sima, Arne Brys, Hanne Struyfs, Ellis Niemantsverdriet, Ellen De Roeck, Christine Bastin, Florence Benoit, Bruno Bergmans, Jean-Christophe Bier, Peter Paul de Deyn, Olivier Deryck, Bernard Hanseeuw, Adrian Ivanoiu, Gaëtane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Evert Thiery, Jos Tournoy, Anne-Marie van Binst, Jan Versijpt, Dirk Smeets, Maria Bjerke, Maura Bellio, Neil P. Oxtoby, Daniel C. Alexander, Annemie Ribbens, Sebastiaan Engelborghs
格式:	Artigo
語言:	Inglês
出版:	BMC 2025-06-01
叢編:	Alzheimer’s Research & Therapy
主題:	Alzheimer’s disease Biomarkers Magnetic resonance imaging Automated volumetry Event-based modelling
在線閱讀:	https://doi.org/10.1186/s13195-025-01788-6
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