Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Membrane protein biogenesis in the endoplasmic reticulum (ER) is complex and failure-prone. The ER membrane protein complex (EMC), comprising eight conserved subunits, has emerged as a central player in this process. Yet, we have limited understanding of how EMC enables insertion and integrity of di...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Lakshmi E Miller-Vedam, Bastian Bräuning, Katerina D Popova, Nicole T Schirle Oakdale, Jessica L Bonnar, Jesuraj R Prabu, Elizabeth A Boydston, Natalia Sevillano, Matthew J Shurtleff, Robert M Stroud, Charles S Craik, Brenda A Schulman, Adam Frost, Jonathan S Weissman
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	eLife Sciences Publications Ltd 2020-11-01
Σειρά:	eLife
Θέματα:	EMC endoplasmic reticulum chaperone holdase electron microscopy membrane protein biogenesis insertase
Διαθέσιμο Online:	https://elifesciences.org/articles/62611
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