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Keratinocyte-specific angiotensin II receptor-associated protein deficiency exacerbates angiotensin II-dependent hypertension via activation of the skin renin-angiotensin system

Abstract The skin has recently been highlighted as a new player regulating blood pressure (BP). Here we show the role of skin renin-angiotensin system (RAS) in hypertension. In human subjects, skin expression of angiotensin II (Ang II) type 1 receptor (AT1R)-associated protein (ATRAP), which inhibit...

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Main Authors: Shinya Taguchi, Kengo Azushima, Kento Kitada, Norihiko Morisawa, Satoshi Kidoguchi, Ryutaro Morita, Kazuya Nakagawa, Atsushi Ishibe, Itaru Endo, Keisuke Kazama, Yasushi Rino, Aya Saito, Sho Kinguchi, Ryu Kobayashi, Taiji Matsusaka, Akio Yamashita, Hiromichi Wakui, Akira Nishiyama, Kouichi Tamura
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60041-8
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