Unleashing high content screening in hit detection – Benchmarking AI workflows including novelty detection

Complex mixtures containing natural products are still an interesting source of novel drug candidates. High content screening (HCS) is a popular tool to screen for such. In particular, multiplexed HCS assays promise comprehensive bioactivity profiles, but generate also high amounts of data. Yet, onl...

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Autors principals:	Erwin Kupczyk, Kenji Schorpp, Kamyar Hadian, Sean Lin, Dimitrios Tziotis, Philippe Schmitt-Kopplin, Constanze Mueller
Format:	Artigo
Idioma:	Inglês
Publicat:	American Association for the Advancement of Science (AAAS) 2022-01-01
Col·lecció:	Computational and Structural Biotechnology Journal
Matèries:	High-content screening Machine learning Deep learning Classifier Novelty detection Bioactives
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2001037022004299
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