Mice with a deletion of the major central myelin protein exhibit hypersensitivity to noxious thermal stimuli: involvement of central sensitization

Null mutations in the gene encoding the major myelin protein of the central nervous system, proteolipid protein 1 (PLP1), cause an X-linked form of spastic paraplegia (SPG2) associated with axonal degeneration. While motor symptoms are the best known manifestations of this condition, its somatosenso...

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Detalhes bibliográficos

Principais autores:	Bérengère Petit, Fabrice Giraudet, Céline Béchon, Laurent Bardin, Paul Avan, Odile Boespflug-Tanguy, Mélina Bégou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2014-05-01
coleção:	Neurobiology of Disease
Assuntos:	Dysmyelinating disease Pain Central sensitization Transgenic mice
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996114000126
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