The tumour microenvironment of pilocytic astrocytoma evolves over time via enrichment for microglia

Abstract Pilocytic astrocytoma (PA) is the commonest low-grade tumour affecting children and is frequently experienced as a chronic disease associated with extended treatment, periods of regrowth, and long-term disability. This contrasts with the view of PA as a benign tumour with positive clinical...

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Hlavní autoři:	Thomas J. Stone, Jessica C. Pickles, Olumide Ogunbiyi, Shireena A. Yasin, Catherine A. Taylor, Saira W. Ahmed, Jane Chalker, Carryl Dryden, Iwona Slodkowska, Emily Pang, Mark Kristiansen, Rachel Williams, Helena Tutill, Charlotte A. Williams, Gaganjit K. Madhan, Leysa Forrest, Tony Brooks, Mike Hubank, Debbie Hughes, Paula Proszek, Grzegorz Pietka, Erin Peat, Darren Hargrave, Thomas S. Jacques
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-02-01
Edice:	Acta Neuropathologica Communications
Témata:	Low-grade glioma Pilocytic astrocytoma Microglia Immune microenvironment
On-line přístup:	https://doi.org/10.1186/s40478-024-01922-9
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