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Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery

Fragment based drug discovery has long been used for the identification of new ligands and interest in targeted covalent inhibitors has continued to grow in recent years, with high profile drugs such as osimertinib and sotorasib gaining FDA approval. It is therefore unsurprising that covalent fragme...

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Autores principales: Kirsten McAulay, Alan Bilsland, Marta Bon
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2022-11-01
Colección:Pharmaceuticals
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Acceso en línea:https://www.mdpi.com/1424-8247/15/11/1366
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