CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

Pregnenolone (P5) is synthesized as the first bioactive steroid in the mitochondria from cholesterol. Clusters of differentiation 4 (CD4+) and Clusters of differentiation 8 (CD8+) immune cells synthesize P5 de novo; P5, in turn, play important role in immune homeostasis and regulation. However, P5’s...

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Hauptverfasser:	Sougata Roy, Sudeep Roy, Bidesh Mahata, Jhuma Pramanik, Marco L. Hennrich, Anne-Claude Gavin, Sarah A. Teichmann
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2023-10-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	pregnenolone lymphosteroid chemoproteomics TH2 click chemistry
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1229703/full
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