Integrating 1H MRS and deuterium labeled glucose for mapping the dynamics of neural metabolism in humans

In the technique presented here, dubbed ‘qMRS’, we quantify the change in 1H MRS signal following administration of 2H-labeled glucose. As in recent human DMRS studies, we administer [6,6′-2H2]-glucose orally to healthy subjects. Since 2H is not detectable by 1H MRS, the transfer of the 2H label fro...

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Hlavní autoři:	Abigail T.J. Cember, Neil E. Wilson, Laurie J. Rich, Puneet Bagga, Ravi Prakash Reddy Nanga, Sophia Swago, Anshuman Swain, Deepa Thakuri, Mark Elliot, Mitchell D. Schnall, John A. Detre, Ravinder Reddy
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2022-05-01
Edice:	NeuroImage
Témata:	Deuterium Glucose Metabolism MRI Spectroscopy Chemical shift imaging
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1053811922001069
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