Biodistribution Analysis of an Anti-EGFR Antibody in the Rat Brain: Validation of CSF Microcirculation as a Viable Pathway to Circumvent the Blood-Brain Barrier for Drug Delivery

Cerebrospinal fluid (CSF) microcirculation refers to CSF flow through brain or spinal parenchyma. CSF enters the tissue along the perivascular spaces of the penetrating arteries where it mixes with the interstitial fluid circulating through the extracellular space. The potential of harnessing CSF mi...

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Principais autores:	Ghazal Naseri Kouzehgarani, Pankaj Kumar, Susan E. Bolin, Edward B. Reilly, Didier R. Lefebvre
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2022-07-01
Series:	Pharmaceutics
Assuntos:	blood-brain barrier brain targeted therapy drug delivery cerebrospinal fluid microcirculation brain biodistribution
Acceso en liña:	https://www.mdpi.com/1999-4923/14/7/1441
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