PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.

Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening fungal infection. To identify molecules that ab...

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Autors principals:	Shantelle L LaFayette, Cathy Collins, Aimee K Zaas, Wiley A Schell, Marisol Betancourt-Quiroz, A A Leslie Gunatilaka, John R Perfect, Leah E Cowen
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2010-08-01
Col·lecció:	PLoS Pathogens
Accés en línia:	http://europepmc.org/articles/PMC2928802?pdf=render
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