Senataxin Attenuates DNA Damage Response Activation and Suppresses Senescence

Oxidative stress, driven by reactive oxygen species (ROS) such as hydrogen peroxide (H₂O₂), induces DNA double-strand breaks (DSBs) that compromise genomic integrity. The DNA Damage Response (DDR), primarily mediated by ATM and ATR kinases, is crucial for recognizing and repair...

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主要な著者:	Mingyang Li, Genbao Shao
フォーマット:	Artigo
言語:	Inglês
出版事項:	MDPI AG 2024-10-01
シリーズ:	Antioxidants
主題:	oxidative stress senataxin SETX DNA double-strand break repair senescence DNA damage response
オンライン･アクセス:	https://www.mdpi.com/2076-3921/13/11/1337
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