Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells

The pathological consequences leading to primary storage, autophagy impairment, impaired mitochondrial dynamics, and endoplasmic reticulum (ER) stress on neural cell dysfunction and apoptosis in metachromatic leukodystrophy (MLD) have been poorly elucidated. In the present study, we generated 2 cell...

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Autors principals:	Mohammad Arif Hossain, Minami Hasegawa-Ogawa, Yoko Manome, Miki Igarashi, Chen Wu, Ken Suzuki, Junko Igarashi, Takeo Iwamoto, Hirotaka James Okano, Yoshikatsu Eto
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2022-06-01
Col·lecció:	Molecular Genetics and Metabolism Reports
Matèries:	Mitophagy ER stress Motor neuron progenitors Motor neurons Apoptosis
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S221442692200012X
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