Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

ABSTRACT CRISPR‐based prime editors (PEs) install precise edits into genomic DNA without generating double‐strand breaks. Their editing efficiency is highly dependent on reverse transcriptases (RTs), but efficient RT candidates remain limited. Here, we identified 19 novel active RTs by screening 558...

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Autors principals:	Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2026-09-01
Col·lecció:	Advanced Science
Matèries:	crop breeding gene therapy hard‐to‐edit prime editors protein engineering RERV (Rattus norvegicus endogenous retrovirus)
Accés en línia:	https://doi.org/10.1002/advs.75888
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