Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation

Most childhood cancers occur sporadically and cannot be explained by an inherited mutation or an unhealthy lifestyle. However, risk factors might trigger the oncogenic transformation of cells. Among other regulatory signals, hypermethylation of RAD9A intron 2 is responsible for the increased express...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Danuta Galetzka, Julia Böck, Lukas Wagner, Marcus Dittrich, Olesja Sinizyn, Marco Ludwig, Heidi Rossmann, Claudia Spix, Markus Radsak, Peter Scholz-Kreisel, Johanna Mirsch, Matthias Linke, Walburgis Brenner, Manuela Marron, Alicia Poplawski, Thomas Haaf, Heinz Schmidberger, Dirk Prawitt
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2022-01-01
Edice:	EXCLI Journal : Experimental and Clinical Sciences
Témata:	rad9a childhood cancer hypermethylation regular body cells somatic mosaicism leukemia dna repair
On-line přístup:	https://www.excli.de/index.php/excli/article/view/4482
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!