The role of Poly-ADP ribose polymerase (PARP) enzymes in chemotherapy-induced cognitive impairments – parallels with other neurodegenerative disorders

Poly (ADP-ribose) polymerase (PARP) enzymes are critical in repairing DNA damage induced by chemotherapy and/or radiation. Due to PARP’s role in DNA repair, inhibiting PARP leads to genomic instability and accumulation of damaged cells in cell cycle arrest. Previous studies have shown that PARP1 act...

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Principais autores:	Dahlia A. Ordaz, Kalpna Gupta, Daniela A. Bota
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-06-01
coleção:	Frontiers in Pharmacology
Assuntos:	PARP (poly(ADP-ribose) PARP inhibitors (PARPi) chemo brain neuroinflamamation chemotherapy
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1615843/full
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