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Effect of the versatile bifunctional chelator AAZTA5 on the radiometal labelling properties and the in vitro performance of a gastrin releasing peptide receptor antagonist

Abstract Background Gastrin Releasing Peptide receptor (GRPr)-based radioligands have shown great promise for diagnostic imaging of GRPr-positive cancers, such as prostate and breast. The present study aims at developing and evaluating a versatile GRPr-based probe for both PET/SPECT imaging as well...

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Principais autores: Michael Hofstetter, Euy Sung Moon, Fabio D’Angelo, Lucien Geissbühler, Ian Alberts, Ali Afshar-Oromieh, Frank Rösch, Axel Rominger, Eleni Gourni
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2020-11-01
Serier:EJNMMI Radiopharmacy and Chemistry
Fag:
Gastrin releasing peptide receptor (GRPr)
AAZTA
Prostate cancer
Imaging
Peptide radionuclide therapy
Online adgang:https://doi.org/10.1186/s41181-020-00115-8
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