Concurrent intracranial hemorrhage and spontaneous tumor Lysis syndrome as the initial presentation of KMT2A::AFF1-rearranged adult ALL: a case report

BackgroundKMT2A::AFF1-rearranged ALL is a high-risk subtype with an aggressive course. However, the simultaneous occurrence of catastrophic intracranial hemorrhage (ICH) and spontaneous tumor lysis syndrome (TLS) as the initial presentation is rare in adult patients and remains poorly characterized...

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Detalhes bibliográficos

Principais autores:	Yuyi Lai, Ligang Zhao, Min Wei, Rongguo Wei
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Oncology
Assuntos:	acute lymphoblastic leukemia hyperleukocytosis intracranial hemorrhage KMT2A::AFF1 fusion tumor lysis syndrome
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1716717/full
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