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A Synthetic Polymicrobial Community Biofilm Model Demonstrates Spatial Partitioning, Tolerance to Antimicrobial Treatment, Reduced Metabolism, and Small Colony Variants Typical of Chronic Wound Biofilms

Understanding chronic wound infection is key for successful treatment and requires accurate laboratory models. We describe a modified biofilm flow device that effectively mimics the chronic wound environment, including simulated wound fluid, a collagen-based 3D biofilm matrix, and a five-species mix...

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Bibliografski detalji
Glavni autori: Ammara Khalid, Alan R. Cookson, David E. Whitworth, Michael L. Beeton, Lori I. Robins, Sarah E. Maddocks
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2023-01-01
Serija:Pathogens
Teme:
Online pristup:https://www.mdpi.com/2076-0817/12/1/118
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