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Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

JCPyV polyomavirus, a member of the human virome, causes progressive multifocal leukoencephalopathy (PML), an oft-fatal demyelinating brain disease in individuals receiving immunomodulatory therapies. Mutations in the major viral capsid protein, VP1, are common in JCPyV from PML patients (JCPyV-PML)...

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Autori principali: Matthew D Lauver, Daniel J Goetschius, Colleen S Netherby-Winslow, Katelyn N Ayers, Ge Jin, Daniel G Haas, Elizabeth L Frost, Sung Hyun Cho, Carol M Bator, Stephanie M Bywaters, Neil D Christensen, Susan L Hafenstein, Aron E Lukacher
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2020-09-01
Serie:eLife
Soggetti:
polyomavirus
neutralizing antibody
progressive multifocal leukoencephalopathy
Cryo EM
subvolume refinement
fab:capsid complex
Accesso online:https://elifesciences.org/articles/61056
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