APOE genotype and sex drive microbiome divergence after microbiome standardization in APOE-humanized mice

ABSTRACT The APOE4 allele is the greatest known genetic factor for sporadic or late-onset Alzheimer’s Disease (LOAD). Gut microbiome (GMB) dysbiosis can lead to poorer outcomes in disease. The intersection of sex, APOE genotype, inflammation, and gut microbiota is incompletely understood. Previous s...

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Detalhes bibliográficos

Principais autores:	Michelle Aries Marchington, Hope Gasvoda, Makayla Michelotti, Fernando Rodriguez-Caro, Ashley Gooman, Anna Perez, Tiffany Hensley-McBain
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-11-01
coleção:	mSphere
Assuntos:	APOE apolipoprotein E APOE 4 microbiome shallow shotgun sequencing GMB
Acesso em linha:	https://journals.asm.org/doi/10.1128/msphere.00429-25
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