Hinge region mediates signal transmission of luteinizing hormone and chorionic gonadotropin receptor

Luteinizing hormone-choriogonadotropin receptor (LHCGR), a class A G protein-coupled receptor (GPCR), plays a pivotal role in the maturation of reproductive organs and embryonic development. Compared with other GPCRs, the subfamily of LHCGR has a large extracellular domain (ECD) to interact with gly...

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Autori principali:	Xinheng He, Jia Duan, Yujie Ji, Lifen Zhao, Hualiang Jiang, Yi Jiang, H. Eric Xu, Xi Cheng
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Association for the Advancement of Science (AAAS) 2022-01-01
Serie:	Computational and Structural Biotechnology Journal
Soggetti:	Glycoprotein hormone receptors G protein-coupled receptors Molecular dynamics simulation Protein dynamics Evolutionary analysis
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2001037022005335
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