Recapitulation of clinical and molecular hallmarks of lipid-induced hepatic insulin resistance in a zonated, vascularized human liver acinus microphysiological system during metabolic dysfunction-associated steatotic liver disease (MASLD) progression

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts ca. 30% of the global population and is very heterogeneous, making it a challenge to develop therapeutics. The heterogeneity arises from genetics, co-morbidities, the microbiome, and lifestyle. To help address this cha...

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Bibliographic Details

Main Authors:	Julio Aleman, Lawrence Vernetti, Mark E. Schurdak, Richard DeBiasio, Greg LaRocca, Vijay K. Yechoor, D. Lansing. Taylor, Andrew M. Stern, Mark T. Miedel
Format:	Artigo
Language:	Inglês
Published:	BMC 2026-04-01
Series:	BMC Biotechnology
Subjects:	Metabolic dysfunction-associated steatotic liver disease (MASLD) Human microphysiology systems (MPS) Metabolic disease mechanism Hepatic steatosis Hepatic insulin resistance Hyperglycemia
Online Access:	https://doi.org/10.1186/s12896-026-01158-6
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