Autonomous drug delivery and scar microenvironment remodeling using micromotor-driven microneedles for hypertrophic scars therapy

Hypertrophic scar is a fibrous hyperplastic disorder that arises from skin injuries. The current therapeutic modalities are constrained by the dense and rigid scar tissue which impedes effective drug delivery. Additionally, insufficient autophagic activity in fibroblasts hinders their apoptosis, lea...

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Detalhes bibliográficos

Principais autores:	Ting Wen, Yanping Fu, Xiangting Yi, Ying Sun, Wanchen Zhao, Chaonan Shi, Ziyao Chang, Beibei Yang, Shuling Li, Chao Lu, Tingting Peng, Chuanbin Wu, Xin Pan, Guilan Quan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-07-01
coleção:	Acta Pharmaceutica Sinica B
Assuntos:	Hypertrophic scar Microneedles Autonomous drug delivery Drug diffusion Autophagy regulation Fibroblast apoptosis
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211383525003235
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