Longitudinal immune profiling after radiation-attenuated sporozoite vaccination reveals coordinated immune processes correlated with malaria protection

BackgroundIdentifying immune processes required for liver-stage sterilizing immunity to malaria remains an open problem. The IMRAS trial comprised 5x immunizations with radiation-attenuated sporozoites resulting in 55% protection from subsequent challenge.MethodsTo identify correlates of vaccination...

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Auteurs principaux:	Fergal J. Duffy, Nina Hertoghs, Ying Du, Maxwell L. Neal, Damian Oyong, Suzanne McDermott, Nana Minkah, Jason Carnes, Katharine V. Schwedhelm, M. Juliana McElrath, Stephen C. De Rosa, Evan Newell, John D. Aitchison, Ken Stuart
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2022-12-01
Collection:	Frontiers in Immunology
Sujets:	malaria vaccine systems immunology radiation-attenuated sporozoites whole blood transcriptional profiling immunophenotyping
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1042741/full
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