TSH Receptor Homodimerization in Regulation of cAMP Production in Human Thyrocytes in vitro

Thyrotropin hormone (TSH) was reported to exhibit biphasic regulation of cAMP production in human thyroid slices; specifically, upregulation at low TSH doses transitioning to inhibition at high doses. We observed this phenomenon in HEK293 cells overexpressing TSH receptors (TSHRs) but in only 25% of...

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Hlavní autoři:	Alisa Boutin, Christine C. Krieger, Bernice Marcus-Samuels, Joanna Klubo-Gwiezdzinska, Susanne Neumann, Marvin C. Gershengorn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2020-04-01
Edice:	Frontiers in Endocrinology
Témata:	inverted U-shaped dose response curve cAMP production phosphoinositide signaling thyrotropin receptor TSHR receptor homodimerization
On-line přístup:	https://www.frontiersin.org/article/10.3389/fendo.2020.00276/full
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