Exploring the effect of pre-clinical Alzheimer’s disease on blood pressure using Mendelian randomisation and parental dementia as an instrumental variable in UK Biobank

Abstract Background Evidence suggests there may be a bidirectional relationship between high blood pressure (BP) and Alzheimer’s disease (AD). It is hypothesised that this is due to cerebral changes during pre-clinical AD that cause elevation of systemic BP. We aimed to test this by exploring the ef...

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Principais autores:	Jennifer C. Palmer, Emma Hart, Emma Anderson, Seth Love, Deborah A. Lawlor
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
coleção:	BMC Medicine
Assuntos:	Blood pressure Pre-clinical Alzheimer’s disease Prospective cohort Instrumental variables Human population
Acesso em linha:	https://doi.org/10.1186/s12916-025-04295-5
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