Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers

Abstract Background The encoding of cell intrinsic drug resistance states in breast cancer reflects the contributions of genomic and non-genomic variations and requires accurate estimation of clonal fitness from co-measurement of transcriptomic and genomic data. Somatic copy number (CN) variation is...

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Главные авторы:	Farhia Kabeer, Hoa Tran, Mirela Andronescu, Gurdeep Singh, Hakwoo Lee, Sohrab Salehi, Beixi Wang, Justina Biele, Jazmine Brimhall, David Gee, Viviana Cerda, Ciara O’Flanagan, Teresa Algara, Takako Kono, Sean Beatty, Elena Zaikova, Daniel Lai, Eric Lee, Richard Moore, Andrew J. Mungall, IMAXT Consortium, Marc J. Williams, Andrew Roth, Kieran R. Campbell, Sohrab P. Shah, Samuel Aparicio
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-07-01
Серии:	Genome Biology
Предметы:	PDX Single-cell RNA sequencing DLP+ single-cell sequencing Cisplatin treatment In-cis/in-trans genes Sensitive/resistant clones
Online-ссылка:	https://doi.org/10.1186/s13059-024-03318-3
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