Differences in F pocket impact on HLA I genetic associations with autoimmune diabetes

IntroductionHuman leukocyte antigen (HLA) I molecules present antigenic peptides to activate CD8+ T cells. Type 1 Diabetes (T1D) is an auto-immune disease caused by aberrant activation of the CD8+ T cells that destroy insulin-producing pancreatic β cells. Some HLA I alleles were shown to increase th...

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Principais autores:	Xu Ren, A. W. Peshala Amarajeewa, M. D. Tharushika Jayasinghe, Malgorzata A. Garstka
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2024-03-01
סדרה:	Frontiers in Immunology
נושאים:	HLA class I antigen presentation peptide binding polymorphism inflammation autoimmune diabetes
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342335/full
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