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Protective Effect of Nasal Colonisation with <i>∆cps/piaA</i> and <i>∆cps/proABC</i><i>Streptococcus pneumoniae</i> Strains against Recolonisation and Invasive Infection

Rationale: Nasopharyngeal administration of live virulence-attenuated <i>Streptococcus pneumoniae</i> strains is a potential novel preventative strategy. One target for creating reduced virulence <i>S. pneumoniae</i> strains is the capsule, but loss of the capsule reduces the duration of <i>S. pneum...

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Main Authors: Elisa Ramos-Sevillano, Giuseppe Ercoli, José Afonso Guerra-Assunção, Philip Felgner, Rafael Ramiro de Assis, Rie Nakajima, David Goldblatt, Kevin Kweku Adjei Tetteh, Robert Simon Heyderman, Stephen Brian Gordon, Daniela Mulari Ferreria, Jeremy Stuart Brown
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-03-01
Series:Vaccines
Subjects:
<i>Streptococcus pneumoniae</i>
capsule
vaccine
<i>psaA</i>
<i>proABC</i>
colonisation
Online Access:https://www.mdpi.com/2076-393X/9/3/261
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