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Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma

Background: Phosphodiesterase 4 selective inhibitor may prevent airway inflammation and remodeling. Objective: The aim of this study was to investigate the effects of KF19514, a phosphodiesterase 4 and 1 dual inhibitor, on chronic airway inflammation and remodeling following chronic exposure to aero...

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Principais autores: Toshiyuki Kita, Masaki Fujimura, Shigeharu Myou, Kazuyoshi Watanabe, Yuko Waseda, Shinji Nakao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2009-01-01
coleção:Allergology International
Assuntos:
airway hyperresponsiveness
airway remodeling
asthma
murine model
PDE inhibitor
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1323893015307061
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