PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain

How PD-L1 expression is regulated in cancer is poorly understood. Here, we report that the ATP-binding activity of ERBB3 pseudokinase regulates PD-L1 gene expression in colorectal cancers (CRCs). ERBB3 is one of the four members of the EGF receptor family, all with protein tyrosine kinase domains. E...

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Hlavní autoři:	Yamu Li, Zhonghua Liu, Yiqing Zhao, Jie Yang, Tsan Sam Xiao, Ronald A. Conlon, Zhenghe Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	KeAi Communications Co., Ltd. 2023-07-01
Edice:	Genes and Diseases
Témata:	Colon cancer ERBB3 Immunotherapy PD-L1 Pseudokinase
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S235230422200304X
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