Development of a human in vitro blood–brain tumor barrier model of diffuse intrinsic pontine glioma to better understand the chemoresistance

Abstract Background Pediatric diffuse intrinsic pontine glioma (DIPG) represents one of the most devastating and lethal brain tumors in children with a median survival of 12 months. The high mortality rate can be explained by the ineligibility of patients to surgical resection due to the diffuse gro...

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Detalhes bibliográficos

Principais autores:	Clémence Deligne, Johan Hachani, Sophie Duban-Deweer, Samuel Meignan, Pierre Leblond, Angel M. Carcaboso, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Fabien Gosselet, Marie-Pierre Dehouck, Caroline Mysiorek
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-06-01
coleção:	Fluids and Barriers of the CNS
Assuntos:	Blood–brain barrier Blood–brain tumor barrier Diffuse intrinsic pontine glioma Chemoresistance Pediatric brain cancer
Acesso em linha:	http://link.springer.com/article/10.1186/s12987-020-00198-0
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