Enhancement of the Solubility and Dissolution Rate of Telmisartan by Surface Solid Dispersions Employing Superdisintegrants, Hydrophilic Polymers and Combined Carriers

Telmisartan (Tel) is a potent antihypertensive drug with a very poor aqueous solubility, especially in pH ranging from 3 to 9 (i.e., biological fluids) that results in poor bioavailability. Our aim was to improve Tel solubility and dissolution rates without the need for expensive multistep procedure...

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Principais autores:	Reem A. Aldeeb, Mohamed Farid El-Miligi, Mohamed El-Nabarawi, Randa Tag, Hany M. S. Amin, A. A. Taha
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-11-01
coleção:	Scientia Pharmaceutica
Assuntos:	telmisartan surface solid dispersions superdisintegrants hydrophilic polymers combined carriers
Acesso em linha:	https://www.mdpi.com/2218-0532/90/4/71
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