Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is associated with abnormal iron homeostasis: implications for patient survival
IntroductionIron is crucial for brain function, but excessive iron is neurotoxic. Abnormally high brain iron accumulation is one of the pathogenic factors in Alzheimer’s disease (AD). Therefore, understanding the mechanistic basis of iron dyshomeostasis in AD is vital for disease mitigation. Calcium...
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| Natura: | Artigo |
| Lingua: | Inglês |
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Frontiers Media S.A.
2024-11-01
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| Serie: | Frontiers in Cell and Developmental Biology |
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| Accesso online: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1469751/full |
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