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Prior dengue virus serotype 3 infection modulates subsequent plasmablast responses to Zika virus infection in rhesus macaques

ABSTRACT Immunodominant and highly conserved flavivirus envelope proteins can trigger cross-reactive IgG antibodies against related flaviviruses, which shapes subsequent protection or disease severity. This study examined how prior dengue serotype 3 (DENV-3) infection affects subsequent Zika virus (...

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Principais autores: Tulika Singh, Itzayana G. Miller, Sravani Venkatayogi, Helen Webster, Holly J. Heimsath, Josh A. Eudailey, Dawn M. Dudley, Amit Kumar, Riley J. Mangan, Amelia Thein, Matthew T. Aliota, Christina M. Newman, Mariel S. Mohns, Meghan E. Breitbach, Madison Berry, Thomas C. Friedrich, Kevin Wiehe, David H. O'Connor, Sallie R. Permar
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2024-03-01
Serier:mBio
Fag:
Zika virus
dengue virus
plasmablast
B cell
neutralizing antibodies
Online adgang:https://journals.asm.org/doi/10.1128/mbio.03160-23
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