Cyclin E modulates vulnerability to CDC7 kinase inhibition

Abstract CCNE1 (cyclin E) is frequently amplified or overexpressed in triple-negative breast cancer (TNBC) as compared with luminal subtypes. Cyclin E is associated with chromosomal instability and poor outcome, and overexpression promotes replication stress (fork stalling) in S-phase through impair...

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主要な著者:	Adam P. Dommer, Robert Kyne, Jianxin Wang, Thomas N. O’Connor, Amnon Koren, Erik S. Knudsen, Agnieszka K. Witkiewicz
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Publishing Group 2026-04-01
シリーズ:	Oncogenesis
オンライン･アクセス:	https://doi.org/10.1038/s41389-026-00613-5
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