Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Abstract Ulcerative colitis (UC) is a chronic inflammatory bowel disease, characterized by focal iron overload. Herein, we reported that γ‐glutamylcysteine (γGC) deletion in UC lesions intensified the disease by depleting intracellular GSH to induce macrophage ferroptosis, leading to macrophage M1 r...

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Detalhes bibliográficos

Principais autores:	Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-08-01
Colecção:	Advanced Science
Assuntos:	ferroptosis M1 reprogramming PI3K/AKT pathway ulcerative colitis
Acesso em linha:	https://doi.org/10.1002/advs.202503903
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