PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

Abstract The innate immune sensor PKR for double-stranded RNA (dsRNA) is critical for antiviral defense, but its aberrant activation by cellular dsRNA is linked to various diseases. The dsRNA-binding protein PACT plays a critical yet controversial role in this pathway. We show that PACT directly sup...

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Principais autores:	Sadeem Ahmad, Tao Zou, Jihee Hwang, Linlin Zhao, Xi Wang, Anton Davydenko, Ilana Buchumenski, Patrick Zhuang, Alyssa R. Fishbein, Diego Capcha-Rodriguez, Aaron Orgel, Erez Y. Levanon, Sua Myong, James Chou, Matthew Meyerson, Sun Hur
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2025-04-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-025-58433-x
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