Serine Protease Inhibitor Kazal Type 1, A Potential Biomarker for the Early Detection, Targeting, and Prediction of Response to Immune Checkpoint Blockade Therapies in Hepatocellular Carcinoma

BackgroundWe aimed to characterize serine protease inhibitor Kazal type 1 (SPINK1) as a gene signature for the early diagnosis, molecular targeting, and prediction of immune checkpoint blockade (ICB) treatment response of hepatocellular carcinoma (HCC).MethodsThe transcriptomics, proteomics, and phe...

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主要な著者:	Jianlong Jia, Latai Ga, Yang Liu, Zhiyi Yang, Yue Wang, Xuanze Guo, Ruichen Ma, Ruonan Liu, Tianyou Li, Zeyao Tang, Jun Wang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2022-07-01
シリーズ:	Frontiers in Immunology
主題:	serine peptidase inhibitor Kazal type 1 (SPINK1) immune checkpoint blockade (ICB) hepatocellular carcinoma (HCC) tumor immune microenvironment (TIME) biomarker
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.923031/full
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