Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics

This study aimed to investigate the effects and underlying mechanisms of tormentic acid (TA) on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. The rats were intragastrically administered with 50% CCl4 for 9 weeks to induce hepatic fibrosis, followed by various agents for 6 weeks. Transc...

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Bibliografske podrobnosti

Principais autores:	Xing Lin, Yuanyuan Wei, Yan Li, Yuhua Xiong, Bin Fang, Cuiyu Li, Quanfang Huang, Renbin Huang, Jinbin Wei
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2022-03-01
Serija:	Frontiers in Pharmacology
Teme:	liver fibrosis tormentic acid transcriptomics metabolomics glycerophospholipid metabolism pathway
Online dostop:	https://www.frontiersin.org/articles/10.3389/fphar.2022.801982/full
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