Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic approach for renal fibrosis

Background: Renal fibrosis—characterized by microcirculatory disturbances and endothelial‐mesenchymal transition (EndMT)—is a major pathological feature of chronic kidney disease (CKD) and remains a significant therapeutic challenge. The mechanosensitive ion channel Piezo1 plays a pivotal role in en...

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Autores principales:	Run Li, Jikai Xia, Chunru Shi, Keying Zhang, Yilun Qu, Guosen He, Zhangning Fu, Lingchen Deng, Ran Liu, Xu Wang, Guangyan Cai, Zheyi Dong, Ping Li, Xiangmei Chen, Quan Hong
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2026-04-01
Colección:	Journal of Advanced Research
Materias:	Paeoniflorin Piezo1 Microcirculation HIF-1α EndMT Renal fibrosis
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2090123225005405
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