Time-course transcriptomics reveals the impact of Treponema pallidum on microvascular endothelial cell function and phenotype

Syphilis, caused by Treponema pallidum subsp. pallidum, is an urgent global public health threat. Syphilis vaccine development has been impeded by limited understanding of the molecular mechanisms that enable T. pallidum to establish and maintain infection. The vascular endothelium is critical for T...

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Hlavní autoři:	Sean Waugh, Mara C. Goodyear, Alloysius Gomez, Akash Ranasinghe, Karen V. Lithgow, Reza Falsafi, Robert E. W. Hancock, Amy H. Lee, Caroline E. Cameron
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-10-01
Edice:	Frontiers in Microbiology
Témata:	syphilis vaccine transcriptomics Treponema pallidum endothelial cell pathogenesis
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1649738/full
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