Two intestinal microbiota-derived metabolites, deoxycholic acid and butyrate, synergize to enhance host defense peptide synthesis and alleviate necrotic enteritis

Abstract Background Necrotic enteritis (NE) is a major enteric disease in poultry, yet effective mitigation strategies remain elusive. Deoxycholic acid (DCA) and butyrate, two major metabolites derived from the intestinal microbiota, have independently been shown to induce host defense peptide (HDP)...

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Κύριοι συγγραφείς:	Dohyung M. Kim, Jing Liu, Melanie A. Whitmore, Isabel Tobin, Zijun Zhao, Guolong Zhang
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2024-03-01
Σειρά:	Journal of Animal Science and Biotechnology
Θέματα:	Bile acids Host defense peptides Metabolites Microbiome Necrotic enteritis Short-chain fatty acids
Διαθέσιμο Online:	https://doi.org/10.1186/s40104-024-00995-9
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