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Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

Abstract Background Eicosapentaenoic acid (EPA, C20:5n-3), docosahexaenoic acid (DHA, C22:6n-3) and arachidonic acid (AA, C20:4n-6) are long-chain polyunsaturated fatty acids (LCPUFAs) with relevant roles in the organism. EPA and DHA are synthesized from the precursor alpha-linolenic acid (ALA, C18:...

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Principais autores: Rodrigo Valenzuela, Francisca Echeverria, Macarena Ortiz, Miguel Ángel Rincón-Cervera, Alejandra Espinosa, María Catalina Hernandez-Rodas, Paola Illesca, Alfonso Valenzuela, Luis A. Videla
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-04-01
coleção:Lipids in Health and Disease
Assuntos:
Hydroxytyrosol
Oxidative stress
Antioxidant capacity
Δ5/Δ6 Desaturase activity
LCPUFA
Liver and extrahepatic tissues
Acesso em linha:http://link.springer.com/article/10.1186/s12944-017-0450-5
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