Sperm-disrupting activity of a root bark fraction of Flueggea virosa (Roxb. ex willd.) royle uncovered using LC-MS/MS profiling and functional evaluation

IntroductionWhile Flueggea virosa (Roxb. Ex Willd.) Royle root bark is traditionally used in several parts of East Africa for fertility regulation, its contraceptive potential has not been systematically investigated. Given the paucity of safe, reversible, non-hormonal contraceptives for women, this...

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Principais autores:	Kehongo M. Nyanguru, Caroline Maina, Mutiat Ibrahim, James Kuria, Ephantus Ndirangu, Sospeter Ngoci Njeru, Abdullahi Abdulraheem, Edwin Murungi, Moses Obimbo, Adeyemi O. Aremu, Aloys Mosima Osano, Samwel Cheruiyot, Margaret O. Ilomuanya, Peter Waweru Mwangi, Elizabeth Kigondu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-07-01
coleção:	Frontiers in Pharmacology
Assuntos:	Acrosin-related activity Flueggea virosa intravaginal contraception LC-MS/MS profiling rabbit model sperm immobilization
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1835308/full
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