Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2‐mutation carriers

Abstract The aldehyde degrading function of the ALDH2 enzyme is impaired by Glu504Lys polymorphisms (rs671, termed A allele), which causes alcohol flushing in east Asians, and elevates the risk of esophageal cancer among habitual drinkers. Recent studies suggested that the ALDH2 variant may lead to...

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Hlavní autoři:	Tomoharu Mori, Yusuke Okamoto, Anfeng Mu, Yoshimi Ide, Akiyo Yoshimura, Noriko Senda, Yukiko Inagaki‐Kawata, Masahiro Kawashima, Hiroyuki Kitao, Eriko Tokunaga, Yasuo Miyoshi, Shozo Ohsumi, Koichiro Tsugawa, Tomohiko Ohta, Toyomasa Katagiri, Shigeru Ohtsuru, Kaoru Koike, Seishi Ogawa, Masakazu Toi, Hiroji Iwata, Seigo Nakamura, Keitaro Matsuo, Minoru Takata
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2023-03-01
Edice:	Cancer Medicine
Témata:	Fanconi anemia hereditary breast and ovarian cancer BRCA1 BRCA2 ALDH2
On-line přístup:	https://doi.org/10.1002/cam4.5430
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