Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models

Abstract Pediatric high grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPGs), are aggressive tumors with a dismal outcome. Radiotherapy (RT) is part of the standard of care of these tumors; however, radiotherapy only leads to a transient clinical improvement. Delta-24-RGD is a g...

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Hlavní autoři:	Naiara Martinez-Velez, Miguel Marigil, Marc García-Moure, Marisol Gonzalez-Huarriz, Jose Javier Aristu, Luis-Isaac Ramos-García, Sonia Tejada, Ricardo Díez-Valle, Ana Patiño-García, Oren J. Becher, Candelaria Gomez-Manzano, Juan Fueyo, Marta M. Alonso
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2019-04-01
Edice:	Acta Neuropathologica Communications
Témata:	pHGG DIPG Radiotherapy Oncolytic virus DNA damage Immune response
On-line přístup:	http://link.springer.com/article/10.1186/s40478-019-0714-6
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